Cabergoline Hyperprolactinaemia Parkinson’s Disease Treat Pramipexole Dihydrochloride
Cabergoline 98% Min
Cabergoline
Produktname: Cabergoline
Anderer Name: 6-allyl-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)ergoline-8-carboxamide; Cabaser; Dostine
CAS: 81409-90-7
MF: C26H37N5O2
MW: 451.6
Chemische Eigenschaften: White Crystalline Solid.
Verwendet: A dopamine D2-receptor agonist. receptor stimulant
Definition : An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (Position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substit ted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson’s disease and of disorders associated with hyperprolactinaemia.
Biologische Aktivität: Selective D 2 -like dopamine receptor agonist (K i values are 0.7, 1.5, 9.0 und 165 nM for D 2 , D 3 , D 4 and D 5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K i = 1.2-20.0 nM for 5-HT 1A , 5-HT 1D , 5-HT 2A and 5-HT 2B ). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.
