Каберголин Гиперпролактинемия Болезнь Паркинсона Лечение прамипексола дигидрохлоридом
Cabergoline 98% Мин
Cabergoline
наименование товара: Cabergoline
Другое имя: 6-allyl-n-[3-(dimethylamino)пропил]-n-(ethylcarbamoyl)ergoline-8-carboxamide; Cabaser; Dostine
КАС: 81409-90-7
МФ: C26H37N5O2
МВт: 451.6
Химические свойства: Белое кристаллическое твердое вещество.
Использование: A dopamine D2-receptor agonist. receptor stimulant
Определение : An N-acylurea that is (8р)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (позиция 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substit ted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson’s disease and of disorders associated with hyperprolactinaemia.
Биологическая активность: Selective D 2 -like dopamine receptor agonist (K i values are 0.7, 1.5, 9.0 а также 165 nM for D 2 , Д 3 , Д 4 and D 5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K i = 1.2-20.0 nM for 5-HT 1A , 5-HT 1D , 5-HT 2A and 5-HT 2B ). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.
