Rimonabant chemical
Rymonabant SR141716 Utrata masy ciała Pharma Chemical ACOMPLIA
Rimonabant (SR141716)
Synonimy: ACOMPLIA;RIMONABANT;RIMONABANT(ACOMPLIA,SR141716);5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidinopyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-;5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide
CAS: 168273-06-1
MF: C22H21Cl3N4O
MW: 463.79
Rimonabant hydrochloride
MF: C22H21Cl3N4O.ClH
MW: 500.25
CAS: 158681-13-1
Rimonabant (also known as SR141716; trade names Acomplia, Zimulti) was an anorectic antiobesity drug. Rimonabant is an inverse agonist for the cannabinoid receptor CB1 and was the first drug approved in that class. Rimonabant is a diet pills developed by the French company Sanofi-Aventis and the first cannabinoid type 1 receptor (CB1) antagonist for obesity treatment by selectively blocking marijuana in the EC system (Cannabinoid-1, CB1) receptors, can significantly reduce body weight, reduce waist circumference, reduce cardiovascular disease and other risk factors, but also can improve blood lipids and insulin resistance and metabolic syndrome, especially for There is a risk of clinical obesity or heart disease.
Rimonabant Pharma materials Chemical Test Specifications (Certyfikat ważności):
|
Nazwa produktu
Nazwa produktu
|
Rimonabant
Rimonabant
|
|
CAS
Nr CAS.
|
168273-06-1
|
Uszczelka
Opakowanie zewnętrzne
|
|
|
MFG
Data produkcji
|
May 14th. 2015
|
EXPIRY DATE
Okres przydatności do spożycia
|
May 13th. 2017
|
|
Products Standard
Standard przyjęty
|
Standard korporacyjny
|
|
Analysis Item
Elementy analizy
|
Quality Standard
Specyfikacja
|
Wyniki
Wyniki
|
|
Assay by (HPLC)
|
99%-101%
|
99.43%
|
|
Characters/appearance
|
White to off White powder
|
Zgodny
|
|
Odor and taste
|
Odorless
|
Zgodny
|
|
Identyfikacja
|
Positive reaction
|
Zgodny
|
|
Mesh size/sieve analysis
|
100% przechodzić 80 mesh
|
Zgodny
|
|
Loss on drying
|
1% Max
|
0.78%
|
|
Water
|
≤2.0%
|
0.1%
|
|
Pozostałość po zapłonie
|
01%Max
|
Zgodny
|
|
Single impurity
|
0.1% Max
|
Zgodny
|
|
Malting point
|
272.25 °C
|
Zgodny
|
|
Bolling point
|
627 .69 °C
|
Zgodny
|
|
Refractive Index
|
N20O1.67
|
Zgodny
|
|
PH
|
50-7.0
|
6.5
|
|
pK Values
|
pK. 11.31(Predicted). pK„ 3. 22 (Predicted)
|
Zgodny
|
|
Solubility
|
Soluble in ethanol (-20 mg/ml). DMSO (25 mg/ml) .DMF (-20mg/ml). and water (< 1 mg/ml)
|
Zgodny
|
|
Heavy Metals
|
NMT 10ppm
|
Zgodny
|
|
Microbiological Control
|
78cfu/g
|
78cfu/g
|
|
Total Plate Count
|
1000 cfu/g Max
|
Negative
|
|
Fungi
|
<100/g
|
Negative
|
|
Salmonella
|
Negative
|
Negative
|
|
Coll
|
negative
|
negative
|
|
Wniosek
Wniosek
|
Wykwalifikowany
|
